Peptic ulcer

Definition:

Peptic ulcer is a common disorder of gastrointestinal system characterized by mucosal damage secondary to pepsin and gastric acid secretion. It usually occurs in the stomach and proximal duodenum. Typical symptoms include episodic burning epigastric pain, loss of appetite, and weight loss. Pain usually occurs two to five hours after meals or on an empty stomach. The most common causes of peptic ulcer are Helicobacter pylori infection and use of nonsteroidal anti-inflammatory drugs (NSAIDs). Smoking increases the risk of ulcer recurrence and slows healing. Most patients are treated successfully with eradication of H. pylori and/or avoidance of NSAIDs, along with the appropriate use of antisecretory therapy. About 25 percent of patients with peptic ulcer have a serious complication such as hemorrhage, perforation, or gastric outlet obstruction. Administration of proton pump inhibitors (PPIs) and endoscopic therapy control most bleeds.

References:

[1]. Ramakrishnan, Kalyanakrishnan, and Robert C Salinas.Peptic ulcer disease.Am Fam Physician. 2007 Oct 1;76(7):1005-12. [Content Brief]

[2]. Fashner, Julia, and Alfred C Gitu. Diagnosis and Treatment of Peptic Ulcer Disease and H. pylori Infection.Am Fam Physician. 2015 Feb 15;91(4):236-42. [Content Brief]

[3]. Weir, D G. Peptic ulceration.Br Med J (Clin Res Ed). 1988 Jan 16;296(6616):195-200. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.