Peptide deformylase, mitochondrial

Definition:

Removes the formyl group from the N-terminal Met of newly synthesized proteins.

References:

[1]. Mona D Lee, et al. Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics. J Clin Invest. 2004 Oct;114(8):1107-16. [Content Brief]

[2]. Sindy Escobar-Alvarez, et al. Structure and activity of human mitochondrial peptide deformylase, a novel cancer target. J Mol Biol. 2009 Apr 17;387(5):1211-28. [Content Brief]

[3]. Alexandre Serero, et al. An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway. J Biol Chem. 2003 Dec 26;278(52):52953-63. [Content Brief]

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