Peptidyl-prolyl cis-trans isomerase FKBP1B

Definition:

Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

References:

[1]. H Arakawa, et al. Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts. Biochem Biophys Res Commun. 1994 Apr 29;200(2):836-43. [Content Brief]

[2]. E Lam, et al. A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. J Biol Chem. 1995 Nov 3;270(44):26511-22. [Content Brief]

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