Peroxisomal membrane protein PEX14

Definition:

Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin.

References:

[1]. Pratima Bharti, et al. PEX14 is required for microtubule-based peroxisome motility in human cells. J Cell Sci. 2011 May 15;124(Pt 10):1759-68. [Content Brief]

[2]. Alexander Neuhaus, et al. A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes. J Biol Chem. 2014 Jan 3;289(1):437-48. [Content Brief]

[3]. M Fransen, et al. Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8087-92. [Content Brief]

[4]. Ana F Dias, et al. The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo. J Biol Chem. 2017 Sep 15;292(37):15287-15300. [Content Brief]

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