Peroxynitrite isomerase THAP4

Definition:

Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region.

References:

[1]. Giovanna De Simone, et al. Mycobacterial and Human Nitrobindins: Structure and Function. Antioxid Redox Signal. 2020 Aug 1;33(4):229-246. [Content Brief]

[2]. Giovanna De Simone, et al. Human nitrobindin: the first example of an all-β-barrel ferric heme-protein that catalyzes peroxynitrite detoxification. FEBS Open Bio. 2018 Nov 9;8(12):2002-2010. [Content Brief]

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