Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

Definition:

Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.

References:

[1]. A Arcaro, et al. Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity. J Biol Chem. 1998 Dec 4;273(49):33082-90. [Content Brief]

[2]. A Arcaro, et al. Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. Mol Cell Biol. 2000 Jun;20(11):3817-30. [Content Brief]

[3]. M Wheeler, et al. Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2. Mol Cell Biol. 2001 Oct;21(19):6660-7. [Content Brief]

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