Phospholipid-transporting ATPase ABCA1

Definition:

Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs.

References:

[1]. Larbi Krimbou, et al. Molecular interactions between apoE and ABCA1: impact on apoE lipidation. J Lipid Res. 2004 May;45(5):839-48. [Content Brief]

[2]. M Marcil, et al. Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux. Lancet. 1999 Oct 16;354(9187):1341-6. [Content Brief]

[3]. Faraz Quazi, et al. Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants. J Biol Chem. 2013 Nov 29;288(48):34414-26. [Content Brief]

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