Phospholipid-transporting ATPase IG

Definition:

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane. Major PS-flippase in immune cell subsets. In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages. Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity).

References:

[1]. Hanayo Nakanishi, et al. Crystal structure of a human plasma membrane phospholipid flippase. J Biol Chem. 2020 Jul 24;295(30):10180-10194. [Content Brief]

[2]. Katsumori Segawa, et al. Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science. 2014 Jun 6;344(6188):1164-8. [Content Brief]

[3]. Nobuto Arashiki, et al. ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia. Haematologica. 2016 May;101(5):559-65. [Content Brief]

[4]. Katsumori Segawa, et al. Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium. J Biol Chem. 2016 Jan 8;291(2):762-72. [Content Brief]

[5]. Hiroyuki Takatsu, et al. Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane. J Biol Chem. 2014 Nov 28;289(48):33543-56. [Content Brief]

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