Pleckstrin homology domain-containing family A member 8

Definition:

Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.

References:

[1]. Giovanni D'Angelo, et al. Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. Nature. 2007 Sep 6;449(7158):62-7. [Content Brief]

[2]. Otilia V Vieira, et al. FAPP2 is involved in the transport of apical cargo in polarized MDCK cells. J Cell Biol. 2005 Aug 15;170(4):521-6. [Content Brief]

[3]. Anna Godi, et al. FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Nat Cell Biol. 2004 May;6(5):393-404. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.