Plexin-B1

Definition:

Receptor for SEMA4D. Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.

References:

[1]. Bert J C Janssen, et al. Structural basis of semaphorin-plexin signalling. Nature. 2010 Oct 28;467(7319):1118-22. [Content Brief]

[2]. Christian H Bell, et al. A dual binding mode for RhoGTPases in plexin signalling. PLoS Biol. 2011 Aug;9(8):e1001134. [Content Brief]

[3]. Silvia Giordano, et al. The semaphorin 4D receptor controls invasive growth by coupling with Met. Nat Cell Biol. 2002 Sep;4(9):720-4. [Content Brief]

[4]. Jakub M Swiercz, et al. Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2. J Cell Biol. 2004 Jun 21;165(6):869-80. [Content Brief]

[5]. Yufeng Tong, et al. Structure and function of the intracellular region of the plexin-b1 transmembrane receptor. J Biol Chem. 2009 Dec 18;284(51):35962-72. [Content Brief]

[6]. Jennifer Aurandt, et al. The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12085-90. [Content Brief]

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