POC1 centriolar protein homolog B

Definition:

Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation. Required for retinal integrity.

References:

[1]. Bodo B Beck, et al. Mutation of POC1B in a severe syndromic retinal ciliopathy. Hum Mutat. 2014 Oct;35(10):1153-62. [Content Brief]

[2]. Magali Venoux, et al. Poc1A and Poc1B act together in human cells to ensure centriole integrity. J Cell Sci. 2013 Jan 1;126(Pt 1):163-75. [Content Brief]

[3]. Chad G Pearson, et al. Basal body stability and ciliogenesis requires the conserved component Poc1. J Cell Biol. 2009 Dec 14;187(6):905-20. [Content Brief]

[4]. Enrico S Atorino, et al. CEP44 ensures the formation of bona fide centriole wall, a requirement for the centriole-to-centrosome conversion. Nat Commun. 2020 Feb 14;11(1):903. [Content Brief]

[5]. Lani C Keller, et al. Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control. Mol Biol Cell. 2009 Feb;20(4):1150-66. [Content Brief]

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