Polyprenol reductase

Definition:

Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).

References:

[1]. Motohide Uemura, et al. Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer. Cancer Sci. 2008 Jan;99(1):81-6. [Content Brief]

[2]. Vincent Cantagrel, et al. SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell. 2010 Jul 23;142(2):203-17. [Content Brief]

[3]. Mohamed Fouad Mansour, et al. Characterization of 5α-reductase activity and isoenzymes in human abdominal adipose tissues. J Steroid Biochem Mol Biol. 2016 Jul;161:45-53. [Content Brief]

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