Polypyrimidine tract-binding protein 3

Definition:

RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U).

References:

[1]. Fiona Robinson, et al. Expression of human nPTB is limited by extreme suboptimal codon content. PLoS One. 2008 Mar 12;3(3):e1801. [Content Brief]

[2]. H Yamamoto, et al. Isolation of a mammalian homologue of a fission yeast differentiation regulator. Mol Cell Biol. 1999 May;19(5):3829-41. [Content Brief]

[3]. Keiko Tano, et al. MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes. FEBS Lett. 2010 Nov 19;584(22):4575-80. [Content Brief]

[4]. Gulzhakhan Sadvakassova, et al. Regulator of differentiation 1 (ROD1) binds to the amphipathic C-terminal peptide of thrombospondin-4 and is involved in its mitogenic activity. J Cell Physiol. 2009 Sep;220(3):672-9. [Content Brief]

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