Poor drug metabolism

Definition:

Many administered drugs are first activated by phase I drug-metabolizing enzymes, such as cytochrome P450 (CYP). There are some defective activity mutants due to CYP polymorphisms. In these cases, drugs are not metabolized, the high drug levels in blood are maintained, and toxic effects appear in the patients.

References:

[1]. A Kaneko, et al. High frequencies of CYP2C19 mutations and poor metabolism of proguanil in Vanuatu. Lancet. 1997 Mar 29;349(9056):921-2. [Content Brief]

[2]. Elena A Gaikovitch, et al. Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population. Eur J Clin Pharmacol. 2003 Aug;59(4):303-12. [Content Brief]

[3]. Takaharu Mizutani, et al. PM frequencies of major CYPs in Asians and Caucasians. Drug Metab Rev. 2003 May-Aug;35(2-3):99-106. [Content Brief]

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