Post-translational modifications (PTMs)

Definition:

Post-translational modifications (PTMs) are an essential regulator of non-functional protein aggregation in the pathogenesis of Neurodegenerative diseases (NDDs). Any alteration in the post-translational mechanism and the protein quality control system, for instance, molecular chaperone, ubiquitin-proteasome system, autophagy-lysosomal degradation pathway, enhances the accumulation of misfolded protein, which causes neuronal dysfunction.

References:

[1]. Rohan Gupta, et al. Post-translational modifications: Regulators of neurodegenerative proteinopathies. Ageing Res Rev. 2021 Jul;68:101336. [Content Brief]

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