Potassium voltage-gated channel subfamily S member 3

Definition:

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity).

References:

[1]. A R Shepard, et al. Electrically silent potassium channel subunits from human lens epithelium. Am J Physiol. 1999 Sep;277(3):C412-24. [Content Brief]

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