Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

Definition:

Required for pre-mRNA splicing as component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction.

References:

[1]. Marieta Gencheva, et al. Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing. Biochem J. 2010 Jul 1;429(1):25-32. [Content Brief]

[2]. Xiaofeng Zhang, et al. Structure of the human activated spliceosome in three conformational states. Cell Res. 2018 Mar;28(3):307-322. [Content Brief]

[3]. Marieta Gencheva, et al. Nuclear retention of unspliced pre-mRNAs by mutant DHX16/hPRP2, a spliceosomal DEAH-box protein. J Biol Chem. 2010 Nov 12;285(46):35624-32. [Content Brief]

[4]. Shengbing Zang, et al. GPKOW is essential for pre-mRNA splicing in vitro and suppresses splicing defect caused by dominant-negative DHX16 mutation in vivo. Biosci Rep. 2014 Dec 12;34(6):e00163. [Content Brief]

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