Presenilin 2 (PS2)

Definition:

Presenilin-2 (PS2) is one of the three proteins that are dominantly mutated in familial Alzheimer's disease (FAD). It forms the catalytic core of the γ-secretase , independently of γ-secretase activity, in the modulation of several cellular processes, such as Ca²⁺ signalling, mitochondrial function, inter-organelle communication, and autophagy.

References:

[1]. Pizzo P, et al. Presenilin-2 and Calcium Handling: Molecules, Organelles, Cells and Brain Networks. Cells. 2020 Sep 25;9(10):2166. [Content Brief]

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