Primary peritoneal carcinoma

Definition:

Female primary peritoneal carcinoma (PPC) has the characteristic of diffuse involvement of the peritoneum by papillary carcinoma in the absence of an obvious primary site and grossly normal ovaries, or minimal involvement. It is histologically indistinguishable from primary epithelial ovarian carcinoma (EOC) and is diagnosed in the absence of another identifiable primary. Most reported PPC cases are primary peritoneal serous papillary carcinoma (PPSPC), while peritoneal mixed epithelial carcinoma (MEC) and malignant mixed Mullerian tumor (MMMT) are rarely reported. Germline BRCA1 mutations in 26% of PPSPC patients was detected. BRCA1 mutation carriers had a higher overall incidence of p53 mutations than wildtype BRCA1 case subjects. It is suggested that p53 has a unique role in the development and progression of BRCA1-related PPSPC.

References:

[1]. Brian M Slomovitz, et al. Emerging therapeutics for primary peritoneal cancer. Expert Opin Emerg Drugs. 2011 Mar;16(1):71-84. [Content Brief]

[2]. Chao Zhang, et al. Advanced primary peritoneal carcinoma: clinicopathological and prognostic factor analyses. J Zhejiang Univ Sci B. 2008 Jun;9(6):435-40. [Content Brief]

[3]. G Cormio, et al. Primary peritoneal carcinoma: a report of twelve cases and a review of the literature. Gynecol Obstet Invest. 2000;50(3):203-6. [Content Brief]

[4]. George Pentheroudakis, et al. Serous papillary peritoneal carcinoma: unknown primary tumour, ovarian cancer counterpart or a distinct entity? A systematic review. Crit Rev Oncol Hematol. 2010 Jul;75(1):27-42. [Content Brief]

[5]. Gillian M Keating, et al. Bevacizumab: a review of its use in advanced cancer. Drugs. 2014 Oct;74(16):1891-1925. [Content Brief]

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