PRKCH upstream open reading frame 2

Definition:

Product of an upstream open reading frame (ORF) of PRKCH which regulates translation of the downstream protein kinase C eta (PKC-eta) ORF. Functions as a repressive element that maintains low basal levels of PKC-eta in growing cells but enhances its expression during stress conditions induced by amino acid starvation in a EIF2AK4/GCN2-dependent manner. In addition to its role in regulating PKC-eta translation, also inhibits the kinase activity of PKC-eta as well as other protein kinases including PRKCD, PRKCQ and PRKCE but not PRKCA, PRKCG or PRKCZ.

References:

[1]. Hadas Raveh-Amit, et al. Translational control of protein kinase Ceta by two upstream open reading frames. Mol Cell Biol. 2009 Nov;29(22):6140-8. [Content Brief]

[2]. Divya Ram Jayaram, et al. Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2018899118. [Content Brief]

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