Probable C-mannosyltransferase DPY19L2

Definition:

Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.; Required during spermatogenesis for sperm head elongation and acrosome formation. Also plays a role in acrosome attachment to the nuclear envelope (By similarity).

References:

[1]. Isabelle Koscinski, et al. DPY19L2 deletion as a major cause of globozoospermia. Am J Hum Genet. 2011 Mar 11;88(3):344-50. [Content Brief]

[2]. Radu Harbuz, et al. A recurrent deletion of DPY19L2 causes infertility in man by blocking sperm head elongation and acrosome formation. Am J Hum Genet. 2011 Mar 11;88(3):351-61. [Content Brief]

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