Proline-rich protein 14

Definition:

Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha. Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit. Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha. Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2.

References:

[1]. M Yang, et al. A novel role of PRR14 in the regulation of skeletal myogenesis. Cell Death Dis. 2015 Apr 23;6(4):e1734. [Content Brief]

[2]. M Yang, et al. PRR14 is a novel activator of the PI3K pathway promoting lung carcinogenesis. Oncogene. 2016 Oct 20;35(42):5527-5538. [Content Brief]

[3]. Andrey Poleshko, et al. The human protein PRR14 tethers heterochromatin to the nuclear lamina during interphase and mitotic exit. Cell Rep. 2013 Oct 31;5(2):292-301. [Content Brief]

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