Proline-rich protein 5-like

Definition:

Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton. Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration. Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress. Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress.

References:

[1]. Brent Holmes, et al. Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress. Cell Signal. 2012 Jan;24(1):309-15. [Content Brief]

[2]. Laura R Pearce, et al. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J. 2007 Aug 1;405(3):513-22. [Content Brief]

[3]. Xiaoqing Gan, et al. PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. Nat Cell Biol. 2012 May 20;14(7):686-96. [Content Brief]

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