Prominin-1

Definition:

May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.

References:

[1]. H Takenobu, et al. CD133 suppresses neuroblastoma cell differentiation via signal pathway modification. Oncogene. 2011 Jan 6;30(1):97-105. [Content Brief]

[2]. Anthony B Mak, et al. Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation. J Mol Biol. 2014 May 29;426(11):2175-82. [Content Brief]

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