Proteasome inhibitor PI31 subunit

Definition:

Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

References:

[1]. S L McCutchen-Maloney, et al. cDNA cloning, expression, and functional characterization of PI31, a proline-rich inhibitor of the proteasome. J Biol Chem. 2000 Jun 16;275(24):18557-65. [Content Brief]

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