Protein AATF

Definition:

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

References:

[1]. Tiziana Bruno, et al. Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb. Cancer Cell. 2002 Nov;2(5):387-99. [Content Brief]

[2]. Jun Xie, et al. AATF protects neural cells against oxidative damage induced by amyloid beta-peptide. Neurobiol Dis. 2004 Jun;16(1):150-7. [Content Brief]

[3]. Qing Guo, et al. AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4. J Biol Chem. 2004 Feb 6;279(6):4596-603. [Content Brief]

[4]. Monica Di Padova, et al. Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter. J Biol Chem. 2003 Sep 19;278(38):36496-504. [Content Brief]

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