Protein AF1q

Definition:

Cofactor for the transcription factor TCF7. Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate.

References:

[1]. Jino Park, et al. AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis. Oncotarget. 2015 Aug 21;6(24):20697-710. [Content Brief]

[2]. Aude Parcelier, et al. AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway. Blood. 2011 Aug 18;118(7):1784-96. [Content Brief]

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