Protein CBFA2T3

Definition:

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation.; Isoform 2 functions as an A-kinase-anchoring protein.

References:

[1]. J Nathan Davis, et al. The ETO (MTG8) gene family. Gene. 2003 Jan 16;303:1-10. [Content Brief]

[2]. Stefano Rossetti, et al. The MTG proteins: chromatin repression players with a passion for networking. Genomics. 2004 Jul;84(1):1-9. [Content Brief]

[3]. Caitlyn W Barrett, et al. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. PLoS One. 2012;7(12):e51205. [Content Brief]

[4]. Parveen Kumar, et al. Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1. PLoS One. 2015 May 14;10(5):e0123725. [Content Brief]

[5]. Parveen Kumar, et al. The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respiration. PLoS One. 2013 Jul 1;8(7):e68502. [Content Brief]

[6]. Raman Kumar, et al. ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription. Mol Cancer Res. 2006 Sep;4(9):655-65. [Content Brief]

[7]. Marina Kochetkova, et al. CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3. Cancer Res. 2002 Aug 15;62(16):4599-604. [Content Brief]

[8]. Robynn V Schillace, et al. Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes. J Immunol. 2002 Feb 15;168(4):1590-9. [Content Brief]

[9]. Vinzon Ibañez, et al. AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation. Cancer Res. 2004 Jul 1;64(13):4547-54. [Content Brief]

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