Protein DDI1 homolog 1

Definition:

Probable aspartic protease (Probable). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity.

References:

[1]. Rhian E White, et al. HIV proteinase inhibitors target the Ddi1-like protein of Leishmania parasites. FASEB J. 2011 May;25(5):1729-36. [Content Brief]

[2]. Molly C Kottemann, et al. Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity. Mol Cell. 2018 Jan 4;69(1):24-35.e5. [Content Brief]

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