Protein FAM168A

Definition:

In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels.

References:

[1]. Yixue Gu, et al. TCRP1 promotes radioresistance of oral squamous cell carcinoma cells via Akt signal pathway. Mol Cell Biochem. 2011 Nov;357(1-2):107-13. [Content Brief]

[2]. Xiaorong Liu, et al. TCRP1 contributes to cisplatin resistance by preventing Pol β degradation in lung cancer cells. Mol Cell Biochem. 2015 Jan;398(1-2):175-83. [Content Brief]

[3]. Bo Peng, et al. Microarray-assisted pathway analysis identifies MT1X & NFκB as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma. PLoS One. 2012;7(12):e51413. [Content Brief]

[4]. Yixue Gu, et al. Cloning and functional characterization of TCRP1, a novel gene mediating resistance to cisplatin in an oral squamous cell carcinoma cell line. FEBS Lett. 2011 Mar 23;585(6):881-7. [Content Brief]

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