Protein furry homolog

Definition:

Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.

References:

[1]. Masanori Ikeda, et al. Furry protein promotes aurora A-mediated Polo-like kinase 1 activation. J Biol Chem. 2012 Aug 10;287(33):27670-81. [Content Brief]

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