Protein GPR108

Definition:

May play a role in intracellular immune modulation by activating NF-kappaB response and attenuating Toll-like-receptor response.; (Microbial infection) Plays an essential function in adeno-associated virus (AAV) transduction across multiple serotypes except AAV5. May play a critical role in mediating the endosomal virus escape or in the AAV virions trafficking from endosomes to the nucleus.

References:

[1]. Amanda M Dudek, et al. GPR108 Is a Highly Conserved AAV Entry Factor. Mol Ther. 2020 Feb 5;28(2):367-381. [Content Brief]

[2]. W Hans Meisen, et al. Pooled Screens Identify GPR108 and TM9SF2 as Host Cell Factors Critical for AAV Transduction. Mol Ther Methods Clin Dev. 2020 Mar 17;17:601-611. [Content Brief]

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