Protein ILRUN

Definition:

Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF. Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP.

References:

[1]. Rebecca L Ambrose, et al. C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response. J Biol Chem. 2018 Jul 6;293(27):10561-10573. [Content Brief]

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