Protein kinase C and casein kinase substrate in neurons protein 2

Definition:

Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus.; (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer. Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes. Involved in lipid droplet formation, which is important for HCV virion assembly.

References:

[1]. Shih Lin Goh, et al. Versatile membrane deformation potential of activated pacsin. PLoS One. 2012;7(12):e51628. [Content Brief]

[2]. Sergei Popov, et al. HIV-1 gag recruits PACSIN2 to promote virus spreading. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7093-7098. [Content Brief]

[3]. Lap P Nguyen, et al. PACSIN2 Interacts with Nonstructural Protein 5A and Regulates Hepatitis C Virus Assembly. J Virol. 2020 Feb 14;94(5):e01531-19. [Content Brief]

[4]. Bart-Jan de Kreuk, et al. The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization. J Biol Chem. 2012 Dec 21;287(52):43438-53. [Content Brief]

[5]. Allen G Sanderlin, et al. RNAi screen reveals a role for PACSIN2 and caveolins during bacterial cell-to-cell spread. Mol Biol Cell. 2019 Aug 1;30(17):2124-2133. [Content Brief]

[6]. Bart-Jan de Kreuk, et al. The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration. J Cell Sci. 2011 Jul 15;124(Pt 14):2375-88. [Content Brief]

[7]. Sai Srinivas Panapakkam Giridharan, et al. Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis. Mol Biol Cell. 2013 Jun;24(11):1776-90, S1-15. [Content Brief]

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