Protein LTO1 homolog

Definition:

The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation. May play a role in the regulation of proline metabolism and ROS production.

References:

[1]. Viktoria Désirée Paul, et al. The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion. Elife. 2015 Jul 16;4:e08231. [Content Brief]

[2]. C Zhai, et al. The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: essential roles in the function and biogenesis of the ribosome. Oncogene. 2014 Jan 23;33(4):484-94. [Content Brief]

[3]. Yosuke Togashi, et al. Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production. Oncotarget. 2014 May 30;5(10):2962-73. [Content Brief]

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