Protein moonraker

Definition:

Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2. May play a role in cilium assembly.

References:

[1]. Joshi Stephen, et al. Mutations in KIAA0753 cause Joubert syndrome associated with growth hormone deficiency. Hum Genet. 2017 Apr;136(4):399-408. [Content Brief]

[2]. Elif Nur Firat-Karalar, et al. Proximity interactions among centrosome components identify regulators of centriole duplication. Curr Biol. 2014 Mar 17;24(6):664-70. [Content Brief]

[3]. Andrew Kodani, et al. Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. Elife. 2015 Aug 22;4:e07519. [Content Brief]

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