Protein naked cuticle homolog 1

Definition:

Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.

References:

[1]. Menno P Creyghton, et al. PR72, a novel regulator of Wnt signaling required for Naked cuticle function. Genes Dev. 2005 Feb 1;19(3):376-86. [Content Brief]

[2]. Menno P Creyghton, et al. PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle. Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5397-402. [Content Brief]

[3]. D Yan, et al. Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14973-8. [Content Brief]

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