Protein NDRG2

Definition:

Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.

References:

[1]. Yanchun Deng, et al. N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. Int J Cancer. 2003 Sep 1;106(3):342-7. [Content Brief]

[2]. Jungwon Hwang, et al. Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor. J Biol Chem. 2011 Apr 8;286(14):12450-60. [Content Brief]

[3]. Eriks A Lusis, et al. Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma. Cancer Res. 2005 Aug 15;65(16):7121-6. [Content Brief]

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