Protein PAT1 homolog 1

Definition:

RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly.; (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV).

References:

[1]. Joerg E Braun, et al. The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa. EMBO J. 2010 Jul 21;29(14):2368-80. [Content Brief]

[2]. Nicoletta Scheller, et al. Identification of PatL1, a human homolog to yeast P body component Pat1. Biochim Biophys Acta. 2007 Dec;1773(12):1786-92. [Content Brief]

[3]. Sevim Ozgur, et al. Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies. Mol Cell Biol. 2010 Sep;30(17):4308-23. [Content Brief]

[4]. Antonio Totaro, et al. The human Pat1b protein: a novel mRNA deadenylation factor identified by a new immunoprecipitation technique. Nucleic Acids Res. 2011 Jan;39(2):635-47. [Content Brief]

[5]. Nicoletta Scheller, et al. Translation and replication of hepatitis C virus genomic RNA depends on ancient cellular proteins that control mRNA fates. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13517-22. [Content Brief]

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