Protein pelota homolog

Definition:

May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs.

References:

[1]. Vera P Pisareva, et al. Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes. EMBO J. 2011 May 4;30(9):1804-17. [Content Brief]

[2]. Zhihao Wu, et al. Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy. Cell Metab. 2018 Jul 3;28(1):130-144.e7. [Content Brief]

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