Protein phosphatase 1 regulatory subunit 35

Definition:

During centriole duplication, plays a role in the centriole elongation by promoting the recruitment of the microtubule-binding elongation machinery through its interaction with RTTN, leading to the centriole to centrosome conversion. In addition, may play a role in the primary cilia assembly (By similarity).

References:

[1]. Chii Shyang Fong, et al. PPP1R35 ensures centriole homeostasis by promoting centriole-to-centrosome conversion. Mol Biol Cell. 2018 Nov 15;29(23):2801-2808. [Content Brief]

[2]. Andrew Michael Sydor, et al. PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTN. Elife. 2018 Aug 31;7:e37846. [Content Brief]

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