Protein phosphatase 1H

Definition:

Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.

References:

[1]. Si Tuen Lee-Hoeflich, et al. PPM1H is a p27 phosphatase implicated in trastuzumab resistance. Cancer Discov. 2011 Sep;1(4):326-37. [Content Brief]

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