Protein sprouty homolog 4

Definition:

Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1. Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin.

References:

[1]. Atsuo Sasaki, et al. Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. Nat Cell Biol. 2003 May;5(5):427-32. [Content Brief]

[2]. Onno C Leeksma, et al. Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1. Eur J Biochem. 2002 May;269(10):2546-56. [Content Brief]

[3]. Yoshikazu Tsumura, et al. Sprouty-4 negatively regulates cell spreading by inhibiting the kinase activity of testicular protein kinase. Biochem J. 2005 May 1;387(Pt 3):627-37. [Content Brief]

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