Protein TFG

Definition:

Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.

References:

[1]. Kristen Witte, et al. TFG-1 function in protein secretion and oncogenesis. Nat Cell Biol. 2011 May;13(5):550-8. [Content Brief]

[2]. Christian Beetz, et al. Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5091-6. [Content Brief]

[3]. Takashi Kanadome, et al. The calcium-binding protein ALG-2 promotes endoplasmic reticulum exit site localization and polymerization of Trk-fused gene (TFG) protein. FEBS J. 2017 Jan;284(1):56-76. [Content Brief]

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