Protein transport protein Sec16A

Definition:

Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Mediates the recruitment of MIA3/TANGO to ERES. Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane. Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183. Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity).

References:

[1]. He Piao, et al. Sec16A is critical for both conventional and unconventional secretion of CFTR. Sci Rep. 2017 Jan 9;7:39887. [Content Brief]

[2]. Annika Budnik, et al. Characterization of human Sec16B: indications of specialized, non-redundant functions. Sci Rep. 2011;1:77. [Content Brief]

[3]. Miharu Maeda, et al. TANGO1 recruits Sec16 to coordinately organize ER exit sites for efficient secretion. J Cell Biol. 2017 Jun 5;216(6):1731-1743. [Content Brief]

[4]. Takayuki Iinuma, et al. Mammalian Sec16/p250 plays a role in membrane traffic from the endoplasmic reticulum. J Biol Chem. 2007 Jun 15;282(24):17632-9. [Content Brief]

[5]. Peter Watson, et al. Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells. Traffic. 2006 Dec;7(12):1678-87. [Content Brief]

[6]. Yan Wu, et al. Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183. PLoS One. 2018 Jan 4;13(1):e0190407. [Content Brief]

[7]. Dibyendu Bhattacharyya, et al. Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization. Mol Biol Cell. 2007 Mar;18(3):839-49. [Content Brief]

[8]. Shusuke Yonekawa, et al. Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12746-51. [Content Brief]

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