Protein unc-119 homolog A

Definition:

Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A.

References:

[1]. Houbin Zhang, et al. UNC119 is required for G protein trafficking in sensory neurons. Nat Neurosci. 2011 Jun 5;14(7):874-80. [Content Brief]

[2]. Ramarao Vepachedu, et al. Unc119 protects from Shigella infection by inhibiting the Abl family kinases. PLoS One. 2009;4(4):e5211. [Content Brief]

[3]. Osman Cen, et al. Identification of UNC119 as a novel activator of SRC-type tyrosine kinases. J Biol Chem. 2003 Mar 7;278(10):8837-45. [Content Brief]

[4]. Magdalena M Gorska, et al. Unc119, a novel activator of Lck/Fyn, is essential for T cell activation. J Exp Med. 2004 Feb 2;199(3):369-79. [Content Brief]

[5]. Kevin J Wright, et al. An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium. Genes Dev. 2011 Nov 15;25(22):2347-60. [Content Brief]

[6]. Shehab A Ismail, et al. Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119. EMBO J. 2012 Oct 17;31(20):4085-94. [Content Brief]

[7]. YuKyung Lee, et al. UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis. Cell Cycle. 2013 Apr 15;12(8):1303-15. [Content Brief]

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