Protein unc-45 homolog A

Definition:

Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).

References:

[1]. Irene Marcos, et al. Cloning, characterization and chromosome mapping of the human SMAP1 gene. Gene. 2002 Jun 12;292(1-2):167-71. [Content Brief]

[2]. Ahmed Chadli, et al. GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. Mol Cell Biol. 2006 Mar;26(5):1722-30. [Content Brief]

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