Protein UXT

Definition:

Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chromatin to the NKX3-1 promoter region. Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm. May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM.; [Isoform 1]: Plays a role in protecting cells against TNF-alpha-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP.

References:

[1]. Huiwu Zhao, et al. UXT is a novel centrosomal protein essential for cell viability. Mol Biol Cell. 2005 Dec;16(12):5857-65. [Content Brief]

[2]. Shaogang Sun, et al. UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome. J Cell Biol. 2007 Jul 16;178(2):231-44. [Content Brief]

[3]. Paolo Mita, et al. Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP. Mol Cell Biol. 2011 Sep;31(17):3639-52. [Content Brief]

[4]. Tijuana N Moss, et al. UXT (Ubiquitously Expressed Transcript) causes mitochondrial aggregation. In Vitro Cell Dev Biol Anim. 2007 Mar-Apr;43(3-4):139-46. [Content Brief]

[5]. Roger McGilvray, et al. UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation. FEBS J. 2007 Aug;274(15):3960-71. [Content Brief]

[6]. Yuefeng Huang, et al. UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation. Mol Biol Cell. 2011 Apr 15;22(8):1389-97. [Content Brief]

[7]. Steven M Markus, et al. Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus. Mol Biol Cell. 2002 Feb;13(2):670-82. [Content Brief]

[8]. Nuria Sánchez-Morgan, et al. UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells. J Cell Biochem. 2017 Aug;118(8):2347-2356. [Content Brief]

[9]. Leyuan Liu, et al. Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity. Genomics. 2002 Jan;79(1):124-36. [Content Brief]

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