Protein Wnt-10a

Definition:

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays a role in normal ectoderm development. Required for normal tooth development. Required for normal postnatal development and maintenance of tongue papillae and sweat ducts. Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae (By similarity). Required for normal expression of KRT9 in foot plant epithelium. Required for normal hair follicle function.

References:

[1]. Qiuping Yuan, et al. Role of WNT10A in failure of tooth development in humans and zebrafish. Mol Genet Genomic Med. 2017 Nov;5(6):730-741. [Content Brief]

[2]. Mingang Xu, et al. WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nat Commun. 2017 Jun 7;8:15397. [Content Brief]

[3]. Lynn Adaimy, et al. Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia. Am J Hum Genet. 2007 Oct;81(4):821-8. [Content Brief]

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