Protein Wnt-10b

Definition:

Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.

References:

[1]. C Christodoulides, et al. WNT10B mutations in human obesity. Diabetologia. 2006 Apr;49(4):678-84. [Content Brief]

[2]. P Wend, et al. The role of WNT10B in physiology and disease. Acta Physiol (Oxf). 2012 Jan;204(1):34-51. [Content Brief]

[3]. Ping Yu, et al. Mutations in WNT10B Are Identified in Individuals with Oligodontia. Am J Hum Genet. 2016 Jul 7;99(1):195-201. [Content Brief]

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